ELISSEEFF, Jennifer H.,GUO, Qiongyu,MAJUMDAR, Shoumyo,SINGH, Anirudha
申请号：
EP15889426
公开号：
EP3285819A4
申请日:
2015.09.10
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen-based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. As a result, a thick, transparent and mechanically strong collagen- based composition was formed. This cyclodextrin-collagen composition holds a great potential to be used as a therapeutic eye patch for corneal repair. Additionally, the composition can support development of multi-layered structures, with different layers promoting different biological properties. Methods for making these inventive compositions and their use are also provided.
