MAHARBIZ, Michel, M.,CARMENA, Jose, M.,ANWAR, Mekhail,PISTER, Kristofer, S.J.,GARCIA, Stefanie, V.
申请号：
USUS2017/041260
公开号：
WO2018/009908A1
申请日:
2017.07.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor； and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation； an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal； and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation. Further described are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also describe are computer systems for operating implantable devices, methods of detecting radiation, methods of treating a solid cancer in a subject, and methods of monitoring a subject for recurrence of a solid cancer.L'invention concerne un dispositif implantable comprenant un élément sensible au rayonnement (tel qu'un transistor) conçu pour moduler un courant en fonction de l'exposition au rayonnement du transistor ； et un dispositif ultrasonore comprenant un transducteur ultrasonore conçu pour émettre une rétrodiffusion ultrasonore qui code l'exposition au rayonnement du transistor. L'invention concerne également un dispositif implantable comprenant un élément sensible au rayonnement (tel qu'une diode) conçu pour générer un signal électrique lorsqu'il rencontre un rayonnement ； un circuit intégré conçu pour recevoir le signal électrique et moduler un courant
