Polymer-siRNA nanoparticle carrier simultaneously linked by charge bond and biodegradable covalent bond and method for producing the same

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专利权人:

コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー

发明人:

キム クワン ミュン,クォン イク チャン,チェ クイウォン,フー ミュン スク,リ スン ヤン,リ ソ ジン

申请号：

JP2010232764

公开号：

JP5969164B2

申请日:

2010.10.15

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof. The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/