PROTÉINES DE FUSION APOM-FC, LEURS COMPLEXES AVEC LA SPHINGOSINE 1-PHOSPHATE (S1P), ET MÉTHODES DE TRAITEMENT DE MALADIES VASCULAIRES ET NON VASCULAIRES
HLA, Timothy T.,SWENDEMAN, Steven L.,DILORENZO, Annarita,SANCHEZ, Theresa
申请号:
EP17851271
公开号:
EP3496737A4
申请日:
2017.08.15
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present disclosure is directed to an engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperone derived from an Apolipoprotein M (ApoM)-Fc fusion protein having an extended half life in vivo. The disclosed ApoM-Fc fusion protein provides a safe, efficient and effective means of delivering S1P to endothelial cells and to all tissues of the body.