CHU, SO MI,추소미,LEE, WON JUNG,이원중,HA, HONG JOO,하홍주,AN, JUNG GI,안정기,LEE, SANG GYUN,이상균,BYUN, YOUNG SEOK,변영석
申请号：
KR1020120081065
公开号：
KR1012927500000B1
申请日:
2012.07.25
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A novel method for preparing oxacephalosporin derivatives is provided to enable quantitative addition of a halogenating agent, thereby reducing a production cost and enhancing yield with excellent stability.CONSTITUTION: A method for preparing oxacephalosporin derivatives of chemical formula 1 comprises the steps of reacting a compound of chemical formula 2 with a halogenating agent under the presence of a base and adding a compound of chemical formula 3 and a reducing agent. The halogenating agent is selected among trichloroisocyanuric acid, N-iodosuccinimide, N-bromosuccinic imide, N-chlorosuccinimide, N-fluorosuccinimide, and a mixture thereof. The halogenating agent is used in a quantity of 1-5 moles per 1 mole of the compound of chemical formula 2.COPYRIGHT KIPO 2013본 발명은 항균제로 유용한 1-옥사세팔로스포린의 합성용 중간체로써 1-옥사세팔로스포린 유도체의 신규한 제조 방법에 관한 것으로, 본 발명의 제조방법은 간단한 할로겐화제를 사용하여, 안정성이 우수하고, 반응공정이 단순하고 반응 컨트롤이 용이하며, 반응시간이 짧아 매우 효율적인 방법이며, 이로 인해 항균제로 유용한 1-옥사세팔로스포린의 제조 수율을 높이는 효과가 있다.
