VRANDERICK, MANON,ST-ONGE, JEAN-LUC,GALLO, MICHELE,GERVAIS, ERIC
申请号：
CA2847022
公开号：
CA2847022C
申请日:
2014.03.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof； (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v)； and (c) an effective amount of one or more compounds of formula (I) (see formula I) wherein R is H, PO3- or (see above formula). The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
