PROBLEM TO BE SOLVED: To provide compositions and methods for promoting bone growth and increasing bone density, and for the treatment of multiple myeloma.SOLUTION: A pharmaceutical composition includes a fusion protein of an activin receptor IIa type (ActRIIa) protein which binds to an activin receptor IIa type (ActRIIa) ligand with a KD of at least 10-7 M, and has an effect to inhibit ActRIIa signaling in a cell, and an Fc region of an immunoglobulin.【課題】骨成長の促進および骨密度の増加、ならびに多発性骨髄腫の処置のための、組成物および方法の提供。【解決手段】少なくとも10-7MのKDでアクチビン受容体IIa型(ActRIIa)リガンドと結合するおよび)細胞におけるActRIIaシグナル伝達を阻害する効果を有する、アクチビン受容体IIa型(ActRIIa)タンパク質と免疫グロブリンのFc部分との融合タンパク質を含む薬学的組成物。【選択図】なし