RABINOWITZ Matthew,GEMELOS George,BANJEVIC Milena,RYAN Allison,DEMKO Zachary,HILL Matthew,ZIMMERMANN Bernhard,BANER Johan
申请号：
RU20130141237
公开号：
RU2671980(C2)
申请日:
2011.11.18
申请国别(地区):
俄罗斯
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: proposed group of inventions relates to medicine. Methods for determining the ploidy status of a chromosome or chromosome segment in a gestating fetus are disclosed. Method comprises carrying out multiplex amplification of at least 1,000 polymorphic loci on a chromosome or a chromosome segment from a sample, which contains free-floating maternal DNA from the mother of the fetus and free-floating fetal DNA using multiple primers in one reaction to obtain a mixture of amplified fetal and maternal genomic DNA of at least 1,000 polymorphic loci.EFFECT: proposed group of inventions provides effective non-invasive methods for the prenatal establishment of ploidy.32 cl, 26 dwg, 4 tbl, 14 ex
