An anti-scatter grid, a detector with such an anti-scatter grid and a radiation imaging system including such a detector with an anti-scatter grid are provided. The anti-scatter grid includes at least one grid wall. The parameters of the grid wall may be adjusted to arrive a uniform scatter-to-primary ratio. The parameters of the grid wall comprise thickness, height, shape, or position of the grid wall, or width of interspace between two grid walls. The detector includes the anti-scatter grid, at least one photosensor, and at least one scintillator. The radiation system includes a radiation generator, a radiation detector with the anti-scatter grid, and a processor.