ALTENBURGER, JEAN-MICHEL,FOSSEY, VALERIE,LASSALLE, GILBERT,PETIT, FREDERIC,VERNIERES, JEAN-CLAUDE,JANIAK, PHILIP
申请号：
ES07823409
公开号：
ES2385614T3
申请日:
2007.08.09
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compounds that respond to formula (I): ** Formula ** in which: X and Y independently represent each other a nitrogen atom or a link -CR3-, where R3 represents a hydrogen or halogen atom or a group alkyl or alkoxy； U represents a hydrogen atom or an NHR7 group, where R7 is a hydrogen atom or an alkyl group； A represents an optionally substituted aryl, heteroaryl or heterocycloalkyl group； W represents a halogen atom, an alkyl group or a halogenoalkyl group； Z represents a bond, a cycloalkylene group or an alkylene group optionally substituted by one or more groups chosen between a halogen atom and the groups: alkyl, hydroxy and alkoxy； B represents: * either a -NR4R5 group, where R4 and R5 independently represent each other a group: alkyl, cycloalkyl, hydroxyalkyl or fluoroalkyl or R4 and R5 form, with the nitrogen atom to which they are attached, a 5 or 6 link cycle, such as a pyr cycle rolidinyl or piperidinyl, optionally substituted by an alkyl group, * or a heterocycle of the following formula: where myn independently represent one another 0, 1 or 2 and where R6 and R7 independently represent each other a hydrogen atom or a group alkyl or cycloalkyl； R1 and R2 represent: * either independently of one another, a hydrogen atom or a group: alkyl, cycloalkyl, phenyl, benzyl or -CH2-indolyl, these groups being eventually substituted by one or more groups chosen between the halogen atoms and the groups: alkyl, fluoroalkyl, alkoxy, hydroxy and -O-CO-alkyl, at least one of R1 or R2 being different from a hydrogen atom, * either R1 and R2 form together, with the carbon atom to which they are attached, a mono or polycyclic system chosen from: cycloalkyl, indanyl, tetrahydropyranyl, piperidine, tetrahydronaphthyl, bicyclo [2.2.1] heptyl, bicyclo [3.3.1] nonyl yadamantyl, said mono or po system being optionally substituted cyclic, in any position (included in a nitrogen atom, if any) by one or more groups chosen from a halogen atom and the groups: alkyl, fluoroalkyl, hydroxy
