Activated nitric oxide donors and methods of making and using the same

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专利权人:

ユニバーシティー オブ ユタ リサーチ ファンデーション

发明人:

シャミ，ポール ジェイ．,コサック，ケン エム．,シャミ,ポール ジェイ.,コサック,ケン エム.

申请号：

JP2010549867

公开号：

JP5529762B2

申请日:

2009.03.05

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment and prevention are also described herein.

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