TANZI, RUDOLPH E.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
TANZI, RUDOLPH E.,WAGNER, STEVEN L.,CHENG, SOAN,MOBLEY, WILLIAM C.
申请号：
EP14779909
公开号：
EP2968296A4
申请日:
2014.03.12
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
There are provided, inner alia, compounds and methods for lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. Since all of the major AB peptide variants, including the pathogenic AB42 as known in the art, are ultimately generated by gamma-secretase-mediated proteolysis of APP-C99 (i.e., the beta-secretase-mediated cleavage product of the amyloid protein precursor IAPPI), one approach to therapeutic intervention (e.g., intervention in Alzheimer's Disease, AD) relates to lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase.
