According to the invention, there is provided a novel romaine lettuce cultivar, designated CVX576-1. CVX576-1 is described as a vigorous romaine cultivar and recommended for the main lettuce growing regions of California and Arizona. It has thick glossy leaves somewhat yellowish in color. This invention thus relates to the seeds of lettuce cultivar CVX576-1, to the plants of lettuce cultivar CVX576-1, to plant parts of lettuce cultivar CVX576-1, to methods for producing a lettuce cultivar by crossing the lettuce cultivar CVX576-1 with another lettuce cultivar, and to methods for producing a lettuce cultivar containing in its genetic material one or more backcross conversion traits or transgenes and to the backcross conversion lettuce plants and plant parts produced by those methods.