1. The compound having the structure of Formula (I): where L is a bond, -CH-, -CH (OH) -, -C (O) -, -CHO-, -OCH-, -SCH, -CHS-, -N (R) -, -N (R) C (O) -, -C (O) N (R) -, -N (R) C (O) N (R) -, -O-, -S-, —S (O) -, —S (O) -, —N (R) S (O) - or —S (O) N (R) -； Ar means substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl； R is optionally substituted C-C1-6alkyl, substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, - (C = O) C-C1-6alkyl, - (C = O) OR, - (C = O) NRR, - (C = O) SR, -GX or G means optionally substituted heterocytes cloalkyl, optionally substituted aryl or optionally substituted heteroaryl； X is optionally substituted cycloalkyl； optionally substituted heterocycloalkyl； optionally substituted aryl, optionally substituted heteroaryl, —OR, —SR or —NRR； R, in each case independently, is H, C-C1-6alkyl, C-heteroalkyl, C-Cycloalkyl or C-heterocycloalkyl； Y is an optionally substituted group selected from alkyl, heteroalkyl, cycloalkyl, aryl and heteroaryl； Z means C (= O), OC (= O), N (R) C (= O), C (= S), S (= O), OS (= O ) or N (R) S (= O), where x is 1 or 2； R, in each case independently, is halogen, —CN, —NO, —OH, —OCF, —OCHF, —OCFH, —CF, -SR, -N (R) S (= O) R, -S (= O) N (R) (R), -S (= O) R, -S (= O) R, -C (= O ) R, -OC (= O) R, -COR, -N (R) (R), -C (= O) N (R) (R), -N (R) C (= O) R, - N (R) C (= O) OR, -N (R) C (= O) N (R) (R), substituted or unsubstituted alkyl , substituted or unsubstituted alkoxy, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted cycloalkyl； R and R, each independently, are H, substituted or unsubstituted C-C1-6alkyl or substituted or unsubstituted C-Cycloalkyl； R, in each case independently, is substituted or unsubstituted C-C1-6alkyl or substituted or unsubstituted C-Cycloalkyl； n is 0-4 ； p is 0-2； R is H or LJW； R and R ar
