PROBLEM TO BE SOLVED: To provide a manufacturing method of 1-piperidyl indazole derivative useful as pharmaceuticals.SOLUTION: There is provided a method of manufacturing 1-piperidyl indazole and/or a radioisotope labeled body represented by the following formula (I) through a process (A-5) after obtaining the following formula (a5) through processes (A-2), (A-3) and (A-4) or through processes (A-6), (A-7) and (A-8) from the following formula (a2). In the formula, R1A to R1E are same or different and represent a C1-6 alkyl group which may be substituted and the like, R2 represents a C3-10 cycloalkyl which may be substituted and the like, Z1 and Z2 represent a 4 to 10 membered saturated ring which may be integrally substituted and P represents a protective group of an amino group.COPYRIGHT: (C)2014,JPO&INPIT【課題】医薬品として有用な1-ピペリジルインダゾール誘導体の製造方法の提供。【解決手段】下記式(I)で表される、1-ピペリジルインダゾール及び/又は放射性同位体標識体を、下記式(a2)から工程(A-2)、(A-3)及び(A-4)を経るか、又は、工程(A-6)、(A-7)及び(A-8)を経て、下記式(a5)を得、さらに工程(A-5)を経て、下記式(I)の化合物を製造する方法。[式中、R1A~R1Eは、同一又は異なって、置換されていてもよいC1-6アルキル等を表し、R2は、置換されていてもよいC3-10シクロアルキル等を表し、Z1及びZ2は、それぞれ一緒になって置換されていてもよい4~10員の飽和環等を表し、Pは、アミノ基の保護基を表す]【選択図】なし
