THE TEXAS A&；M UNIVERSITY SYSTEM;TRUSTEES OF TUFTS COLLEGE
发明人:
Robert C. Alaniz,Arul Jayaraman,Kyongbum Lee
申请号：
US16085912
公开号：
US20200123498A1
申请日:
2017.03.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure provides methods and compositions for affecting the development of antigen presenting cell (APC, e.g., a macrophage or dendritic cell). The methods include maturing an APC, promoting anti-inflammatory phenotype, promoting development of a T regulatory cell (Treg) from a naive T cell. The methods generally include exposing an APC to a tryptophan derived microbiota metabolite (TDMM), such as an anti-inflammatory or pro-mucosal TDMM, and permitting the APC to mature. In some embodiments, the conditioned APC is exposed to a naive T cell to further promote development of a T regulatory cell (Treg). In some embodiments, the TDMM is selected from the group consisting of indole, indole-3-acetate, 5-hydroxyindole, and indole-3-pyruvate.
