BIONTECH CELL &； GENE THERAPIES GMBH;TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄTS MAINS
发明人:
Petra OEHM,Mario PERKOVIC,Ugur SAHIN,Tim BEISSERT
申请号：
US16645757
公开号：
US20200283497A1
申请日:
2018.09.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention embraces a RNA replicon that can be replicated by a replicase of alphavirus origin and comprises an open reading frame encoding a chain of a T cell receptor or of an artificial T cell receptor. Such RNA replicons are useful for expressing a T cell receptor or an artificial T cell receptor in a cell, in particular an immune effector cell such as a T cell. Cells engineered to express such T cell receptor or artificial T cell receptor are useful in the treatment of diseases characterized by expression of antigens bound by the T cell receptor or artificial T cell receptor.
