KOREA INSTITUTE OF CERAMIC ENGINEERING AND TECHNOLOGY
发明人:
CHANG, Jeong Ho,장정호,LEE, Hye Sun,이혜선
申请号：
KRKR2014/000209
公开号：
WO2014/109550A1
申请日:
2014.01.08
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to an antibacterial bone filling composition and a preparation method therefor, and more specifically, to an antibacterial bone filling composition containing caffeic acid phenethyl ester, which is an active ingredient of propolis, and a preparation method therefor. The antibacterial bone filling composition of the present invention contains caffeic acid phenethyl ester, which is an active ingredient of natural propolis, of which the stability problems such as reverse mutation, a micronucleus test and the like capable of occurring during administration to the human body are identified, and has antibacterial and anti-inflammatory effects, and thus it is possible to prevent the generation of fungi, which is the cause of secondary infection occurring during a surgical operation, without using additional antibiotics.La présente invention concerne une composition antibactérienne de remplissage osseux et son procédé de préparation, et plus particulièrement une composition antibactérienne de remplissage osseux contenant un ester phénéthylique dacide caféique, qui est un principe actif de propolis, et son procédé de préparation. La composition antibactérienne de remplissage osseux de la présente invention contient un ester phénéthylique dacide caféique, qui est un principe actif de propolis naturelle, dont les problèmes de stabilité tels que ceux liés à la mutation inverse, à un test du micronoyau et autres pouvant se produire lors de ladministration au corps humain sont identifiés, et présente des effets antibactériens et anti-inflammatoires, et permet ainsi de prévenir lapparition de champignons, qui est la cause de surinfection se produisant au cours dune opération chirurgicale, sans utiliser dantibiotiques supplémentaires.본 발명은 항균 골충진 조성물 및 이의 제조방법에 관한 것으로서, 더욱 상세하게는 프로폴리스의 활동성분인 카페인산에스테르(caffeic acid phenethyl ester)를 함유하는 것을 특징으로 하는 카페인산에스테르 함유 항균 골충진 조성물 및 이의 제조방법에 관한 것이다. 본 발명에 의한 항균 골 충진 조성물은 인체 내에 투여 시 발생할 수 있는 복귀돌연변이, 소핵시험 등의 안정성 문제가
