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Tetrahydrotriazine compounds to treat diseases related to AMPK activity
专利权人:
Poxel
发明人:
CRAVO, Daniel,HALLAKOU-BOZEC, Sophie,MESANGEAU, Didier,ELBAWAB, Samer
申请号:
ES09799313
公开号:
ES2573266T3
申请日:
2009.12.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I): ** Formula ** in which R1, R2 each, independently of each other, means H or A, R3, R4 each, independently of each other, means H, A, alkenyl having 2-6 C atoms, alkynyl having 2-6 C, Ar or Het atoms, R5, R6 each, independently of each other, means H, A, (CH2) nAr, (CH2) mOAr, (CH2) mOA or (CH2) mOH, R5 and R6 together also mean alkylene having 2, 3, 4 or 5 C atoms, in which a CH2 group can be replaced by O, NH or NA and / or in which 1 atom of H can be replaced by OH, Ar means phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OA, OH, COOH, COOA, CN, NH2, NHA , NA2, SO2A and / or COA, Het means a saturated, unsaturated or aromatic mono-, bi- or tricyclic heterocycle having 1 to 4 atoms of N, O and / or S, which may be unsubstituted or mono-, di - or trisubstituted by Hal, A, OH, OA, NH2, (CH2) nAr, NHA, NA2, COOH, COOA and / or>; = O (carbonyl oxygen), A means unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms can be replaced by F, or cyclic alkyl having 3- 7 atoms of C, Hal means F, Cl, Br or I, m means 1, 2, 3, 4, 5 or 6, and n represents 0, 1 or 2, and / or one of its physiologically acceptable salts for use in the Prophylactic or therapeutic treatment and / or monitoring of diseases that are produced, mediated and / or propagated by the activity of the protein kinase activated by AMP, where the diseases are selected from the group consisting of cancer and inflammation.Compuesto de fórmula (I):**Fórmula** en la que R1, R2 cada uno, independientemente uno de otro, significan H o A, R3, R4 cada uno, independientemente uno de otro, significan H, A, alquenilo que tiene 2-6 átomos de C, alquinilo que tiene 2-6 átomos de C, Ar o Het, R5, R6 cada uno, independientemente uno de otro, significan H, A, (CH2)nAr, (CH2)mOAr, (CH2)mOA o (CH2)mOH, R5 y R6 juntos también significan alquileno que tienen 2, 3, 4 o 5 átomos de C, en el que un grupo CH2 puede estar reemplazado por O,
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