A novel therapeutic agent for organ disease, in particular, a therapeutic agent for liver disease is provided. It has been found that a diarylsulfide or diarylether derivative having 2-amino-1,3-propanediol structure, the compound that act as a sphingosine-1-phosphate receptor agonist, and a pharmaceutically acceptable salt and hydrate thereof are used as effective therapeutic agents for various diseases in organs, in particular liver diseases. The diarylsulfide or diarylether derivative is represented by the following general formula (1):
