(57)< Abstract > Being the chemical compound which possesses affinity in the 5-HT6 receptor, it possesses general structural formula I, when in formula, R is the basis of structural formula II, as for R when R1 is SO2 Ar structural formula displaying II or III basis A - E the one from N, as for remainder is the CH basis R1 SO2 Ar and C (O) is selected from the group which consists of Ar, CH2 Ar and Ar R2, R3, R4 from the group of H and alkyl is selected by independence As for the ---, when there is one double bond simultaneously to ring, under conditions, displaying single bond or double bond As for n integer 1 - 3 As for Z, as for Z when the --- double bond with C, as for Z when the --- single bond it is CH or N As for Ar the chemical compound which becomes the medical supply which remedies the condition where 5-HT6 receptor obstruction of the separation illness and the like which is the optional aryl basis is related. < Conversion 1 >5-HT6受容体に親和性を有する化合物であって、一般構造式Iを有し、式中、Rが構造式IIの基であるとき、R1がSO2Arである場合のRは構造式II又はIIIの基を表しA~Eの1つがNで、残りはCH基でありR1はSO2Ar、C(O)Ar、CH2Ar及びArからなる群より選択されR2、R3、R4はH及びアルキルの群より独立に選択され---は、環には同時に1つの二重結合があるとの条件で、単結合又は二重結合を表しnは1~3の整数Zは、---が二重結合の場合のZはCで、---が単結合の場合のZはCH又はNでありArは任意のアリール基である分裂病などの5-HT6受容体阻害が関係する病状を治療する医薬品となる化合物。【化1】
