UNIVERSITY OF HOUSTON SYSTEM;TRUSTEES OF TUFTS COLLEGE
发明人:
Gregory Cuny,Chalada Suebsuwong,Alexei Degterev
申请号：
US16496503
公开号：
US20200030303A1
申请日:
2018.03.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
