#$%^&*AU2018204187A120180705.pdf#####Abstract The invention is directed to a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, a bone graft substitute cement made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement. The particulate composition of the invention comprises calcium sulfate hemihydrate (CSH) powder of at least 50wt% based on total weight of the particulate composition in combination with p-tricalcium phosphate (p-TCP) powder or granules with a porous morphology, and typically also in combination with a brushite-forming calcium phosphate mixture (i.e. monocalcium phosphate monohydrate (MCMP), non-porous P-TCP granules and/or non-porous p-TCP powder), in modulating/reducing resorption rate of the cement as compared to a cement composition solely comprising calcium sulfate hemihydrate. Upon mixing the particulate composition with an aqueous mixing solution comprising water which may include additives selected from sodium chloride, glycolic acid among others, a hardened triphasic cement comprising brushite and calcium sulfate dihydrate (CSD) is typically formed. The particulate composition includes accelerant particles for conversion of CSH to CSD, as well as the cement formed will become a highly porous matrix of calcium phosphate due to relatively quick resorption rate of CSH whilst providing excellent scaffolding for bone ingrowth. The specific powder component ratios, the use of porous P-TCP, and/or the use of a mixing solution comprising sodium chloride in the glycolic acid solution contribute, at least in part, to the enhanced setting properties of the bone graft substitute here.
