BROWN, ADRIAN ST. CLAIR,布朗 安卓恩 圣 克莱尔,布朗 安卓恩 聖 克萊爾,布朗 安卓恩 圣 克莱尔,布朗 安卓恩 聖 克萊爾
申请号：
TW105120825
公开号：
TW201718535A
申请日:
2016.06.30
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
This disclosure relates to the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone. The disclosure also relates to pharmaceutical compositions comprising the crystalline fumarate salt of (S)-[3,4-difluoro-2- (2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone. The disclosure also relates to methods of treating cancers comprising administering to a patient in need thereof the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone.本發明係關於(S)-[3,4-二氟-2-(2-氟-4-碘苯胺基)苯基][3-羥基-3-(哌啶-2-基)氮雜環丁烷-1-基]-甲酮之結晶反丁烯二酸鹽。本發明亦係關於包含該(S)-[3,4-二氟-2-(2-氟-4-碘苯胺基)苯基][3-羥基-3-(哌啶-2-基)氮雜環丁烷-1-基]-甲酮之結晶反丁烯二酸鹽的醫藥組成物。本發明亦係關於治療癌症之方法，該等方法包括向有需要之患者投與該(S)-[3,4-二氟-2-(2-氟-4-碘苯胺基)苯基][3-羥基-3-(哌啶-2-基)氮雜環丁烷-1-基]-甲酮之結晶反丁烯二酸鹽。
