Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie nauki Federalnyj issledovatelskij tsentr khimicheskoj fiziki im. N.N. Semenova Rossijskoj akademii nauk (FITS KHF RAN)
发明人:
Olkhov Anatolij Aleksandrovich (RU),Ольхов Анатолий Александрович (RU),Burya Gennadij Fedorovich (RU),Буря Геннадий Федорович (RU),Astakhov Ivan Yurevich (RU),Астахов Иван Юрьевич (RU),Kurnosov Aleksa
申请号：
RU2019121392
公开号：
RU0002721880C1
申请日:
2019.07.09
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to embodiments of methods of increasing regenerative potential of implanted material for restorative surgery. In the first embodiment, it is made of non-conductive polymer by application of coating from bioresorbable biopolymer onto implanted material. First, on the surface of the implanted material made from a non-electroconductive polymer, 100–200 nm thick conductive layer is formed, which is then coated with a bioresorbable biopolymer by electrostatic moulding from a polymer solution in an organic solvent, having electrical conductivity of 9–10 mcS/cm, in the form of a layer of microfibres with a diameter of up to 5000 nm and thickness of 15–50 mcm from a bioresorbable biopolymer: polyhydroxybutyrate, polylactide or mixtures thereof. In the second embodiment, when making the implanted material from metal, the bioresorbable biopolymer coating on the implanted material is applied by electrostatic moulding from a solution of a polymer in an organic solvent having specific conductivity of 9–10 mc/cm, in the form of a layer of microfibres with a diameter of not more than 1400 nm and a thickness of not less than 50 mcm from a bioresorbable biopolymer: polyhydroxybutyrate, polylactide or mixtures thereof.EFFECT: technical result is higher efficiency and multiple increase in specific surface of biopolymer layer made of fibres of submicron size, having conductive and adhesive properties.3 cl, 2 dwgИзобретение относится к области медицины, а именно к вариантам способов повышения регенерационного потенциала имплантируемого материала для восстановительной хирургии. В первом варианте изготавливают из неэлектропроводного полимера путем нанесения на имплантируемый материал покрытия из биорезорбируемого биополимера. Сначала на поверхности имплантируемого материала, изготовленного из неэлектропроводного полимера, создают токопроводящий слой толщиной 100-200 нм, на который затем наносят покрытие из биорезорбируемого б
