University of Florida Research Foundation Incorporated
发明人:
Brad E. Hoffman
申请号：
US16679102
公开号：
US20200138978A1
申请日:
2019.11.08
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed are AAV viral-based vector compositions useful in delivering a variety of nucleic segments, including those encoding therapeutic polypetides to selected mammalian host cells for use in therapeutic autoimmune modalities, including, for example, the in vivo induction of immunological tolerance via a liver-directed AAV-based gene therapeutic regimen for treating and/or ameliorating autoimmune disorders such as multiple sclerosis.
