Robert Miller;Aniko Takacs-Cox;I. David MacDonald;Nancy Harrison
发明人:
Nancy Harrison,I. David MacDonald,Aniko Takacs-Cox,Robert Miller
申请号：
US12845600
公开号：
US08329208B2
申请日:
2010.07.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast； that is prior to food intake in the morning.
