Methods are disclosed comprising transmitting ultrasound waves to a plurality of regions of a brain of a subject via one or more probes, receiving ultrasound echoes corresponding to the transmitted ultrasound waves, determining a parameter based on the ultrasound echoes for each region of the plurality of regions, determining a time course for each parameter, and one or more of: comparing the time courses for each region of the plurality of regions to determine a pulsatility measurement for each region of the plurality of regions and comparing the time courses to one or more of, a known time course in normal brain tissue and a known time course in abnormal brain tissue to classify each region of the plurality of regions as comprising normal brain tissue or abnormal brain tissue.
