Ruprecht-Karls-Univeristat Heidelberg;Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V.
发明人:
Offermanns, Stefan,Swiercz, Jakub,Worzfeld, Thomas
申请号：
AU2012215438
公开号：
AU2012215438A1
申请日:
2012.02.09
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention concerns the field of cancer therapy. In particular, it relates to an antagonist of a B-type plexin which prevents the interaction of the B-type plexin with ErbB-2 for use as a medicament, in particular, for treating metastasizing cancer. The present invention also contemplates a method for identifying an antagonist which prevents the interaction of a B-type plexin with ErbB-2. Finally, the invention provides for a polynucleotide encoding a B-type plexin polypeptide which lacks a functional intracellular domain and the said polypeptide.
