THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER
发明人:
申请号：
EP05732272.9
公开号：
EP1735445B1
申请日:
2005.03.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.
