Implementations of the present invention provide devices, systems, and methods for engaging tissue and/or cells forming an occlusion in a body lumen (e.g., in a vessel). More specifically, embodiments of the present invention involve securing at least a portion of the occlusion as well as removing at least a portion of the occlusion from the body lumen. Accordingly, devices, systems, and methods described herein may increase passageway through the body lumen, which, in some instances, may improve and/or at least partially restore fluid flow therethrough.
