An adjustable breast examination device enhances comfort for an individual by adjusting to accommodate variously sized breasts. The device includes a slot extending into a housing. Each of a plurality of plates is interchangeably positionable in the slot. Each plate has a respective cavity extending into a surface of the plate such that each plate may receive a human breast in the cavity. Each cavity is uniquely sized relative to each other the cavity wherein the plates correspond to a plurality of unique breast sizes. An examination mechanism is coupled to the housing and positioned such that the examination mechanism examines the human breast positioned in the cavity of a selected one of the plates positioned in the slot.