Stephen Chappell Mitchell;Daniel E. Afar;Rene S. Hubert;Kahan Leong;Arthur B. Raitano;Douglas C. Saffran
发明人:
Daniel E. Afar,Rene S. Hubert,Kahan Leong,Arthur B. Raitano,Douglas C. Saffran,Stephen Chappell Mitchell
申请号：
US13134650
公开号：
US08414898B2
申请日:
2011.06.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
