Methods are provided for using doxorubicin active agents in which reduced hosttoxicity isobserved. Aspects of the methods including administering to a subject aneffective amount of adoxorubicin active agent in conjunction with a doxorubicin toxicity-reducingadjuvant, e.g., anitrone compound, or a nitrone compound in combination with abisdioxopiperazine compound.Also provided are compositions for use in practicing the subject methods. Themethods andcompositions find use in a variety of different applications, including in thetreatment of a varietyof different disease conditions.(see above formula)
