使用有機酸助溶之４－甲基－３－［［４－（３－吡啶基）－２－嘧啶基］胺基］－Ｎ－５－（４－甲基－１Ｈ－咪唑－１－基）－３

发明人:: LI, SHOUFENG,李守峰,KUMAR, SARAN,库玛　沙拉恩,庫瑪　沙拉恩,KAVIMANDAN, NIKHIL JAVANT,卡威曼登　尼希尔　杰凡特,卡威曼登　尼希爾　傑凡特,LU, ENXIAN,卢恩先,盧恩先,库玛沙拉恩,庫瑪沙拉恩,卡威曼登尼希尔杰凡特,卡威曼登尼希爾傑凡特

摘要：: Soluble pharmaceutical compositions of nilotinib or a pharmaceutically acceptable salt thereof were invented using one or more organic acids that function as a solubilizing agent, increasing the bioavailability of nilotinib and supressing the food effect associated with certain compositions of nilotinib. The pharmaceutical compositions are in the form of solid oral dosage forms, including capsules and tablets.本發明係關於尼勒替尼(nilotinib)或其醫藥上可接受的鹽之可溶性醫藥組合物，其使用一或多種有機酸作為助溶劑以提高尼勒替尼之生物利用率並抑制與尼勒替尼之某些組合物有關的食物效應。該等醫藥組合物係呈固體口服劑型的形式，包括膠囊及錠劑。