SOLUBLE ITRACONAZOLE: GLASS SYSTEM, MULTI UNIT PARTICULATE SYSTEM AND TABLETS, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
A method of manufacturing itraconazole oral dosage from that is substantially free of residual solvents like methylene chloride, an enhanced in vitro dissolution rate and solubility is disclosed. The current invention embodies following steps: i. a novel glass system fabrication with a hydrophilic polymer by dissolving in suitable organic solvents ii. coating of this glass system on organic soluble supports to yield multiparticulate systems, iii. Mixing of these multiparticulate systems with fast disintegrating dummy granules, iv. Compression of the blend to obtain uniform tablets and v. Film coating of the tablets to achieve the required elegance and features. The products of such methods and methods of use thereof are also mentioned.
