The present invention includes endometriosis, amenorrhea, irregular menstruation, uterine fibroids, uterine fibroids, polycystic ovarian disease, lupus erythematosus, hirsutism, precocious puberty, short stature, acne, alopecia Sexual steroid-related neoplasms, gonadotropin-producing pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, fertility regulation, and infertility, and sex hormone-related diseases, and Alzheimer Provided are gonadotropin-releasing hormone receptor antagonists and pharmaceutical compositions comprising the antagonists that can be useful in the prevention or treatment of disease.本発明は、子宮内膜症、無月経、月経不順、子宮筋腫、子宮類線維腫、多嚢胞性卵巣疾患、紅斑性狼瘡、多毛症、思春期早発症、低身長症、ざ瘡、脱毛症、生殖腺ステロイド依存性新生物、ゴナドトロピン産生性下垂体腺腫、睡眠時無呼吸、過敏性大腸症候群、月経前症候群、良性前立腺肥大症、受胎調節、および不妊症などの性ホルモン関連性疾患、ならびにアルツハイマー病の予防または治療に有用であり得る、ゴナドトロピン放出ホルモン受容体アンタゴニストおよび該アンタゴニストを含む医薬組成物を提供する。
