Wonseon Choi;Rainer Wolber;Ludger Kolbe;Vincent J. Hearing
发明人:
Vincent J. Hearing,Wonseon Choi,Ludger Kolbe,Rainer Wolber
申请号：
US13805638
公开号：
US20130095053A1
申请日:
2011.06.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed herein are compositions and methods of using such compositions to modulate pigmentation and proliferation of a melanocyte, such as to prevent or treat skin disorders, including skin cancer or for use for cosmetic purposes. In one example, a method of modulating pigmentation of a melanocyte includes contacting the melanocyte (such as a human melanocyte) with an agent that modulates neuregulin-1 (NRG-1) activity, such as an agent that increases or decreases NRG-1 activity, thereby modulating pigmentation of the melanocyte. In one particular example, the method of increasing melanocyte pigmentation or proliferation can be used to reduce UV skin damage, including that associated with skin cancer. In another example, the method of decreasing melanocyte pigmentation can be used to treat a skin pigmentation disorder associated with undesired increased skin pigmentation.
