David Paul Humphreys,Ralph Adams,James Heads,Shirley Jane Peters
申请号：
US16717671
公开号：
US20200157204A1
申请日:
2019.12.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid； and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
