AGENT FOR IMPROVING DEFECTIVE STRUCTURE OF PROTEOLIPID PROTEIN 1, AND AGENT FOR PREVENTION OR TREATMENT OF DISEASE OR SYMPTOM CAUSED BY DEFECTIVE STRUCTURE OF PROTEOLIPID PROTEIN 1, AND USE THEREFOR
PROBLEM TO BE SOLVED: To provide means for substantially improving a defective structure of proteolipid protein 1 (PLP1).SOLUTION: A agent for improving a defective structure of proteolipid protein 1(PLP1) contains a compound represented by formula (I-1-1) or (I-2-1), its stereoisomer or a salt thereof, or their solvates as active ingredients. There is also provided a pharmaceutical composition used for prevention or treatment of a disease or symptom caused by a defective structure of PLP1, containing the compound, its stereoisomer or a pharmaceutically acceptable salt thereof as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】プロテオリピドタンパク質1（PLP1）の構造不全を実質的に改善する手段の提供。【解決手段】式（I-1-1）又は（I-2-１）で代表される化合物、その立体異性体若しくはそれらの塩、又はそれらの溶媒和物を有効成分として含む、プロテオリピドタンパク質1（PLP1）の構造不全の改善剤。前記化合物、その立体異性体若しくはそれらの製薬上許容される塩を有効成分として含む、PLP1の構造不全に起因する疾患又は症状の予防又は治療に使用するための医薬組成物。【選択図】なし
