The present invention provides a process for preparing revaprazan hydrochloride, which comprises (1) preparation of 4-hydroxy-2- (4-fluoroaniline) -5,6-dimethylpyrimidine, (2) 4-chloro-2 Including preparation of-(4-fluoroaniline) -5,6-dimethylpyrimidine, (3) preparation of revaprazan hydrochloride, the process is simple in operation, the product purity is high, the yield is high, and the industrial It has advantages such as adapting to production. [Selection] Figure 1本発明は、レバプラザン塩酸塩の調製方法を提供し、該方法は（１）４－ヒドロキシ－２－（４－フルオロアニリン）－５，６－ジメチルピリミジンの調製、（２）４－クロロ－２－（４－フルオロアニリン）－５，６－ジメチルピリミジンの調製、（３）レバプラザン塩酸塩の調製を含み、該方法は操作が簡単で、生成物の純度が高く、収率が高く、工業的生産に適合するなどの利点を有する。【選択図】図１
