GREGORY, MATTHEW ALAN,GAISSER, SABINE,PETKOVIC, HRVOJE,MOSS, STEVEN
申请号：
CA2492153
公开号：
CA2492153C
申请日:
2003.07.16
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to production of polyketides and other naturalproducts and to libraries of compounds and individual novel compounds. Oneimportant area is the isolation and potential use of novel FKBP-ligandanalogues and host cells that produce these compounds. The invention isparticularly concerned with methods for the efficient transformation ofstrains that produce FKBP analogues and recombinant cells in which clonedgenes or gene cassettes are expressed to generate novel compounds such aspolyketide (especially rapamycin) FKBP-ligand analogues, and to processes fortheir preparation, and to means employed therein (e.g. nucleic acids, vectors,gene cassettes and genetically modified strains).
