An end effector (100) for use with a surgical stapler, the end effector comprising: a staple cartridge (220) having a tissue contact surface, a first side surface and a second side surface opposite the first lateral surface； an anvil plate (310) having a tissue contact surface, a first lateral surface and a second lateral surface opposite the first lateral surface； a cartridge reinforcement (500a) detachably disposed on the contact surface with the tissue of the staple cartridge； an anvil reinforcement (500b) detachably disposed on the contact surface of the anvil plate tissue； a proximal cartridge anchoring element (S2) that passes through a proximal portion of the cartridge reinforcement； a distal cartridge anchoring element (S1) that passes through a distal portion of the cartridge reinforcement； a proximal anvil plate anchoring element (S4) that crosses a proximal portion of the anvil reinforcement； a distal anvil plate anchoring element (S3) that crosses a distal portion of the anvil reinforcement, characterized in that: the first and second lateral surfaces of the staple cartridge have overmolded areas (242a, 242b, 244a, 244b) made of a polymeric material disposed near a proximal and distal portion thereof； the first and second lateral surfaces of the anvil plate have overmolded areas (332a, 332b, 334a, 334b) made of a polymeric material disposed near a proximal and distal portion thereof； the first and second ends of the proximal cartridge anchoring element (S2) are attached to the respective proximal overmolded areas (244a, 244b) of the first and second lateral surfaces of the staple cartridge； the first and second ends of the distal cartridge anchoring element (S1) are attached to the respective overmolded distal zones (242a, 242b) of the first and second lateral surfaces of the staple cartridge； the first and second ends of the proximal anvil plate anchoring element (S4) are attached to the respective proximal (334a, 334b) overmoulded areas of the first an
