Systems and methods for providing alignment of instruments and/or prostheses in various surgical operations are provided herein. The systems and methods generally include one or more sensors coupled to a patient's bones or other surgical tools, the sensors can detect their position and orientation in space and communicate this information to a processor. The processor can utilize the information to display data to a surgeon or other user regarding the position, angle, and alignment of a patient's bones, surgical tools, and prostheses. Further, the one or more sensors can be aligned to the patient's anatomy using a patient-specific alignment guide that interfaces with a portion of the patient's anatomy in a single position/orientation.
