UMANA PABLO,JEAN-MAIRET JOEL,BAILEY JAMES E (DECEASED) REPRESENTED BY BAILEY SEAN -,BAILEY SEAN
申请号：
NZ60311102
公开号：
NZ603111A
申请日:
2002.08.05
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a glycoengineered antibody that specifically binds the human CD20 antigen, wherein said antibody has a decreased proportion of non-bisected complex oligosaccharides having the m/z value of 1486 Daltons and an increased proportion of bisected hybrid or galactosylated complex oligosaccharides having the m/z values of 1664, 1810, and 1826 Daltons relative to a corresponding, non-glycoengineered anti-CD20 antibody, and wherein the glycoengineered antibody reaches the maximal ADCC activity of the corresponding non-glycoengineered anti-CD20 antibody at an antibody concentration that is approximately five to ten-fold lower as a result of the glycoengineering.
