The United States of America; as represented by the Secretary; Department of Health and Human Ser.
发明人:
Xiaoyuan Chen,Seulki Lee,Lei Zhu
申请号：
US15337461
公开号：
US20170143851A1
申请日:
2016.10.28
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are imaging agents having the following Formula I:wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.
