用於治療囊性纖維化（ＣＦ）之吡啶及吡嗪衍生物农业专利-农业学术服务平台

发明人:: BAETTIG, URS,柏堤　邬斯,柏堤　鄔斯,BALA, KAMLESH JAGDIS,巴拉　卡麦许　贾迪,巴拉　卡麥許　賈迪,BUDD, EMMA,巴德　艾玛,巴德　艾瑪,EDWARDS, LEE,艾德华兹　里,艾德華茲　里,HOWSHAM, CATHERINE,豪夏　凯瑟琳,豪夏　凱瑟琳,HUGHES, GLYN,修杰斯　葛林,修傑斯　葛林,LEGRAND, DARREN MARK,里葛兰,柏堤邬斯,柏堤鄔斯,巴拉卡麦许贾迪,巴拉卡麥許賈迪,巴德艾玛,巴德艾瑪,艾德华兹里,艾德華茲里,豪夏凯瑟琳,豪夏凱瑟琳,修杰斯葛林,修傑斯葛林

摘要：: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sicca, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.本發明提供吡啶及吡嗪衍生物，其恢復或增強突變型及/或野生型CFTR之功能以治療以下疾病：囊性纖維化、原發性纖毛運動障礙、慢性支氣管炎、慢性阻塞性肺病、哮喘、呼吸道感染、肺癌、口乾症及乾性角膜結膜炎或便秘(IBS、IBD、類鴉片誘發之便秘)。本發明亦涵蓋包含該等衍生物之醫藥組合物。