Injection system includes an injector head that is configured to control delivery of a designated fluid to a patient. The injector head includes a syringe interface along an active side of the injector head. The syringe interface has a receiving cavity that is configured to receive a syringe barrel. A side cover has a syringe opening therethrough. The side cover is sized and shaped to cover at least a portion of the active side of the injector head such that the receiving cavity and the syringe opening align with each other to form a port that receives the syringe barrel.