PAYLOAD AND LINKER DESIGNS FOR PLATINUM-ACRIDINE ANTICANCER AGENTS AND METHODS THEREOF

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专利权人:

Wake Forest University

发明人:

Ulrich Bierbach,Xiyuan Yao,Hanwen Wang

申请号：

US16642074

公开号：

US20200181185A1

申请日:

2018.08.28

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and/or enhance the activity of the platinum compound.

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中国工程科技知识中心

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http://www.ckcest.cn/home/