Coe, Jotham Wadsworth,Allen, John Arthur,Davoren, Jennifer Elizabeth,Dounay, Amy Beth,Efremov, Ivan Viktorovich,Gray, David Lawrence Firman,Guilmette, Edward Raymond,Harris, Anthony Richard,Helal, Ch
申请号：
AU2013343104
公开号：
AU2013343104A1
申请日:
2013.10.29
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof； processes and intermediates for preparation of； and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced β- arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.
